COVID Vaccines Put Anti-Science Activists to Shame
It turns out that, despite the destruction and heartbreak caused by the COVID pandemic, there is a silver lining: Scientists from academia, government, and industry worked together and, using the tools of biotechnology, created multiple vaccines that surely will put an end to the worst of the pandemic sometime in 2021. In short, they proved that science works, particularly that which comes from industry. Though politicians and the public love to hate Big Ag and Big Pharma, everybody comes begging for help when the going gets tough.
The change in public attitude is tangible. A headline in the Financial Times declared, "Covid vaccines offer Big Pharma a chance of rehabilitation." In its analysis, the FT says that the pharmaceutical industry is widely reviled because of the high prices it charges for its drugs, among other things, but the speed with which the industry developed COVID vaccines may allow for its reputation to be refurbished.
The Media's Role in Promoting Anti-Biotech Activism
Of course, the media is partly to blame for the pharmaceutical industry's dismal reputation in the first place because of journalists' penchant for oversimplifying complicated stories and pinning blame on an easy scapegoat. While the pharmaceutical industry is far from angelic and places a hefty price tag on its products in the U.S., often gone unmentioned is the fact that high drug prices are the result of multiple factors, including lack of competition (even among generic drugs), foreign price controls that allow citizens of other countries to "free load" off of American consumers, and a deliberately opaque drug supply chain (that involves not only profit-maximizing pharmaceutical manufacturers but "middlemen" like distributors). But why delve into such nuance when it's easier to point to villains like Martin Shkreli?
Big Ag has been subjected to identical mistreatment by the media, with outlets such as the New York Times among the biggest offenders. One article it published compared pesticides to "Nazi-made sarin gas," and another spread misinformation about a high-profile biotech scientist. The website Undark, whose stated mission is "true journalistic coverage of the sciences," once published an opinion piece written by a person who works for an anti-GMO organization and another criticizing Monsanto for its reasonable efforts to defend itself from disinformation. These aren't cherry-picked examples. Overall, the media clearly has taken sides: Science is great, unless it's science from industry.
If the scientific community can use the powerful techniques of biotechnology to cure a previously unknown infectious disease in less than a year, then why shouldn't it be able to cure genetic diseases in humans?
Now, the very same media – which has portrayed the pharmaceutical and biotech industries in the worst possible light, often for political or ideological reasons – is wondering why so many Americans are reluctant to get a COVID vaccine. Perhaps their reportage has something to do with it.
Tech Strikes Back
For years, the agricultural, pharmaceutical, and biotech industries fought back, but to no avail. GMOs are feared, pharma is hated, and biotech is misunderstood. Regulatory red tape abounds. But that may be all about to change, not because of a clever PR campaign, but thanks to the successful coronavirus vaccines produced by the pharma/biotech industry.
All of the major vaccines were created using biotechnology, broadly defined as the use of living systems and organisms to develop products intended to improve human life or the planet. The Pfizer/BioNTech and Moderna vaccines rely on mRNA (messenger RNA), which is essentially a molecular "photocopy" of the more familiar genetic material DNA. The mRNA molecules were tweaked using biotech and then shown to be 95% effective at preventing COVID in human volunteers. The AstraZeneca/Oxford vaccine is based on an older technology that genetically modifies a harmless virus to resemble an immunological target, in this case, SARS-CoV-2. Their vaccine is 62% to 90% effective.
Even better, the pharma/biotech industry showed that it can work hand-in-hand with the government, for instance the FDA, to produce vaccines in record-breaking time. Operation Warp Speed provided some financing to facilitate this process. History will look back at this endeavor and likely conclude that the unprecedented level of cooperation to develop a vaccine in less than 12 months was one of the greatest triumphs in public health history. (The bungled slow rollout is another story.)
Perhaps the most important lesson that society will learn is that the scientific method works.
The pharma/biotech industry has thus gained tremendous momentum. For the first time it seems, those who are opposed to scientific progress and biotechnology are on the defensive. If the scientific community can use the powerful techniques of biotechnology to cure a previously unknown infectious disease in less than a year, then why shouldn't it be able to cure genetic diseases in humans? Or create genetically modified crops that are resistant to insects and drought? Or use genetically modified mosquitoes to help fight against killer diseases like malaria? The arguments against biotechnology have been made exponentially weaker by the success of the coronavirus vaccine.
Perhaps the most important lesson that society will learn is that the scientific method works. We observed (by collecting samples of an unknown virus and sequencing its genome), hypothesized (by predicting which parts of the virus would trigger an immune response), experimented (by recruiting tens of thousands of volunteers into clinical trials), and concluded (that the vaccines worked). It was a thing of pure beauty.
Thanks to all the players involved – from Big Government to Big Pharma – we are beginning the process of being rescued from a modern-day plague. Let us hope that this scientific success also deals a fatal blow to the forces of ignorance that have held back technological progress for decades.
[Editor's Note: LeapsMag is an editorially independent publication that receives program support from Leaps by Bayer. LeapsMag's founding in 2017 predates Bayer's acquisition of Monsanto in 2018. All content published on LeapsMag is strictly free of influence, censorship, and oversight from its corporate sponsor. Read more about LeapsMag's organizational independence here.]
In 1962, the world was a remarkably different place: Neil Armstrong had yet to take his first steps on the lunar surface, John F. Kennedy was serving as president of the United States, and the Beatles were still a few years away from superstardom, having just recorded their first single.
The word “measles” was also a household name. Measles, which still exists in parts of the world today, is a highly contagious viral infection that typically causes fever, cough, muscle pain, fatigue, and a distinctive red rash. Measles was so pervasive around the world in 1962 that most children had gotten sick with it before the age of fifteen—but even though it was common, it was far from harmless. Measles killed around 400 to 500 people per year in the United States, and approximately 2.6 million people each year worldwide. Countless others suffered severe complications from measles, such as permanent blindness.
Tragedy hits home
Author Roald Dahl at his Buckinghamshire home with Olivia, daughter Chantal, and wife Patricia Neal in 1960.
Ben Martin / Getty Images
That year, British author Roald Dahl was beginning to make a name for himself, having just published his best-selling book James and the Giant Peach. Dahl, who would go on to write some of the most well-loved children’s books of the century, lived in southern England with his wife and three children. One day, Dahl and his wife, actress Patricia Neal, received word that there was an outbreak of measles at his daughters’ school.
While some parents quarantined their children, many others also considered measles a harmless childhood disease. Neal later recalled in her autobiography that a family member had advised her to “let the girls get measles,” thinking it would strengthen their immune systems and be “good for them.” Reluctantly, Dahl and Neal let their two school-aged children, Olivia and Chantal, continue school. Olivia, then aged seven, fell sick with the measles not long after that.
Neither Dahl nor Neal were terribly concerned about Olivia’s infection. Dahl would write later that it seemed to be taking its “usual course,” and the two would read and spend time together while Olivia rested. After a few days of fever and fatigue, Dahl wrote, Olivia seemed like she was “well on the road to recovery.”
But one afternoon, as the two sat on Olivia’s bed making animals out of pipe cleaners, Dahl noticed that Olivia’s “fingers and her mind were not working together.” When Dahl asked how she was feeling, Olivia replied, “I feel all sleepy.”
Within an hour, Dahl wrote, Olivia was unconscious. Within 12 hours, she was dead.
Olivia died of measles encephalitis, an inflammation of the brain caused by an infection. Approximately 1 in 1,000 people infected with measles develop encephalitis, and of those who develop it, between 10 and 20 percent will die.
Dahl was overcome with grief and wracked with guilt for being unable to prevent his daughter’s death. Mourning, Dahl threw himself into his writing and, in his spare time, spent hours lovingly constructing a rock garden on Olivia’s grave in a local churchyard.
After Olivia’s death, Dahl wrote sixteen novels and several collections of short stories, including Matilda, Fantastic Mr. Fox, and Willy Wonka and the Chocolate Factory, which garnered him worldwide acclaim. His most influential piece of writing, however, wasn’t written until 1986.
A father's plea
Roald Dahl and the open letter he wrote in 1986, encouraging parents to vaccinate their children against measles.
By 1986, measles was no longer the global health threat that it had been in the 1960s, thanks to a measles vaccine that became available just one year after Olivia had died. Still, in the United Kingdom alone, approximately 80,000 people every year were infected with measles. This bothered Dahl, especially since measles rates in the United States had dropped by 98 percent compared to pre-vaccine years. “Why do we have so much measles in Britain when the Americans have virtually gotten rid of it?,” Dahl was reported to have said.
So Dahl set out to prevent a tragedy like Olivia’s from happening again. With encouragement from several prominent public health activists, Dahl wrote an open letter addressed to parents in the UK. The letter recounted his daughter’s death from encephalitis and begged parents to protect their own children from measles:
“...there is today something that parents can do to make sure that this sort of tragedy does not happen to a child of theirs. They can insist that their child is immunised [sic] against measles. I was unable to do that for Olivia in 1962 because in those days a reliable measles vaccine had not been discovered. Today a good and safe vaccine is available to every family and all you have to do is to ask your doctor to administer it.”
Dahl went on to say that although many parents still viewed measles as a harmless illness, he knew from experience that it was not. Measles was capable of causing disability and death, Dahl wrote, whereas a child had a better chance of “choking on a chocolate bar” than developing any serious complication from the vaccine. Dahl ended his letter by saying how happy he knew Olivia would be “if only she could know that her death had helped to save a good deal of illness and death among other children.”
Dahl’s letter was published in early 1986 and distributed to local healthcare workers, schools, and to parents of children who were particularly at risk. As the letter circulated, vaccination rates continued to climb year after year.
Thirty-one years after Dahl’s letter was published, and 55 years after Olivia’s death, the World Health Organization declared in 2017 that measles had officially been eradicated for the first time in the UK thanks to high rates of vaccination.
A small step back
As vaccination rates decline, measles is now making a strong comeback in the United States and elsewhere.
Today, vaccination rates for the measles are in decline, and countries like the UK and the US, who had once eradicated measles completely, are now seeing a comeback. The Centers for Disease Control and Prevention (CDC) recently reported that between December 1, 2023 and January 23, 2024, 23 cases of measles had been confirmed across multiple states. The majority of these cases, they reported, were among children and adolescents who had traveled internationally and had not yet been vaccinated even though they were eligible to do so.
Roald Dahl passed away in 1990, but fortunately, his writing continues to live on. While readers can explore fantastical worlds through his novels and short stories, they can also look back to a reality when tragic deaths like Olivia’s happened far too often. The difference is that today, thanks to modern science, we now have the tools to stop them.
Sarah Watts is a health and science writer based in Chicago.
On today’s episode of Making Sense of Science, I’m honored to be joined by Dr. Paul Song, a physician, oncologist, progressive activist and biotech chief medical officer. Through his company, NKGen Biotech, Dr. Song is leveraging the power of patients’ own immune systems by supercharging the body’s natural killer cells to make new treatments for Alzheimer’s and cancer.
Whereas other treatments for Alzheimer’s focus directly on reducing the build-up of proteins in the brain such as amyloid and tau in patients will mild cognitive impairment, NKGen is seeking to help patients that much of the rest of the medical community has written off as hopeless cases, those with late stage Alzheimer’s. And in small studies, NKGen has shown remarkable results, even improvement in the symptoms of people with these very progressed forms of Alzheimer’s, above and beyond slowing down the disease.
In the realm of cancer, Dr. Song is similarly setting his sights on another group of patients for whom treatment options are few and far between: people with solid tumors. Whereas some gradual progress has been made in treating blood cancers such as certain leukemias in past few decades, solid tumors have been even more of a challenge. But Dr. Song’s approach of using natural killer cells to treat solid tumors is promising. You may have heard of CAR-T, which uses genetic engineering to introduce cells into the body that have a particular function to help treat a disease. NKGen focuses on other means to enhance the 40 plus receptors of natural killer cells, making them more receptive and sensitive to picking out cancer cells.
Paul Y. Song, MD is currently CEO and Vice Chairman of NKGen Biotech. Dr. Song’s last clinical role was Asst. Professor at the Samuel Oschin Cancer Center at Cedars Sinai Medical Center.
Dr. Song served as the very first visiting fellow on healthcare policy in the California Department of Insurance in 2013.He is currently on the advisory board of the Pritzker School of Molecular Engineering at the University of Chicago and a board member of Mercy Corps, The Center for Health and Democracy, and Gideon’s Promise.
Dr. Song graduated with honors from the University of Chicago and received his MD from George Washington University. He completed his residency in radiation oncology at the University of Chicago where he served as Chief Resident and did a brachytherapy fellowship at the Institute Gustave Roussy in Villejuif, France. He was also awarded an ASTRO research fellowship in 1995 for his research in radiation inducible gene therapy.
With Dr. Song’s leadership, NKGen Biotech’s work on natural killer cells represents cutting-edge science leading to key findings and important pieces of the puzzle for treating two of humanity’s most intractable diseases.
- Paul Song LinkedIn
- NKGen Biotech on Twitter - @NKGenBiotech
- NKGen Website: https://nkgenbiotech.com/
- NKGen appoints Paul Song
- Patient Story: https://pix11.com/news/local-news/long-island/promising-new-treatment-for-advanced-alzheimers-patients/
- FDA Clearance: https://nkgenbiotech.com/nkgen-biotech-receives-ind-clearance-from-fda-for-snk02-allogeneic-natural-killer-cell-therapy-for-solid-tumors/Q3 earnings data: https://www.nasdaq.com/press-release/nkgen-biotech-inc.-reports-third-quarter-2023-financial-results-and-business