A New Web Could be Coming. Will It Improve Human Health?
The Web has provided numerous benefits over the years, but users have also experienced issues related to privacy, cybersecurity, income inequality, and addiction which negatively impact their quality of life. In important ways, the Web has yet to meet its potential to support human health.
Now, engineers are in the process of developing a new version of the Web, called Web3, which would seek to address the Web’s current shortcomings through a mix of new technologies.
It could also create new problems. Industrial revolutions, including new versions of the Web, have trade-offs. While many activists tend to focus on the negative aspects of Web3 technologies, they overlook some of the potential benefits to health and the environment that aren’t as easily quantifiable such as less stressful lives, fewer hours required for work, and a higher standard of living. What emerging technologies are in the mix to define the new era of the digital age, and how will they contribute to our overall health and well-being?
In order to answer these questions, I have identified three major trends that may help define the future landscape of Web3. These include more powerful machine intelligence that could drive improvements in healthcare, decentralized banking systems that allow consumers to bypass middlemen, and self-driving cars with potential to reduce pollution. However, it is the successes of the enabling technologies that support these goals—improvements in AI, blockchain and smart contracts, and fog computing—that will ultimately define Web3.
Machine Intelligence and Diagnosing Diseases
While the internet is the physical network equipment and computers that keep the world connected, the Web is one of the services that run on the internet. In 1989, British scientist Tim Berners-Lee invented the World Wide Web and, when Web1 went live in 1991, it consisted of pages of text connected by hyperlinks. It remained that way until 2004 with the introduction of Web2, which provided social media websites and let users generate content in addition to consuming it passively.
The Semantic Web could expand the impact of new cognitive skills for machines by feeding data to AI in more readily accessible formats. This will make machines better at solving hard problems such as diagnosing and treating complex diseases.
For the most part, Web2 is what we still have today but, from the beginning, Berners-Lee, now an MIT professor, envisaged a much more sophisticated version of the Web. Known as the Semantic Web, it would not only store data, but actually know what it means. The goal is to make all information on the Internet “machine-readable,” so it can be easily processed by computers, like an Excel sheet full of numbers as opposed to human language. We are now in the early stages of the Semantic Web, which incorporates his vision. For example, there is already a cloud of datasets that links thousands of servers without any form of centralized control. However, due to the costs and technological hurdles related to converting human language into something that computers can understand, the Semantic Web remains an ongoing project.
Currently, AI is only able to perform certain tasks, but it can already make healthcare business practices more efficient by leveraging deep learning to analyze data in supply chains. DeepMind, the company that developed AI for defeating chess masters, has also made huge advances in figuring out protein folding and misfolding, which is responsible for some diseases. Currently, AI is not that useful for diagnosing and treating many complex diseases. This is because deep learning is probabilistic, not causal. So, it is able to understand correlation, but not cause and effect.
Like the Web, though, AI is evolving, and the limitations of deep learning could be overcome in the foreseeable future. A number of government programs and private initiatives are dedicated to better understanding human brain complexity and equipping machines with reasoning, common sense, and the ability to understand cause and effect. The Semantic Web could expand the impact of these new cognitive skills by feeding data to AI in more readily accessible formats. This will make machines better at solving hard problems such as diagnosing and treating complex diseases, which involve genetic, lifestyle, and environment factors. These powerful AIs in the realm of healthcare could become an enduring and important feature of Web3.
Blockchain, Smart Contracts and Income Inequality
The Web2 version of the digital age was certainly impactful in altering our lifestyle both positively and negatively. This is predominately because of the business model used by companies such as Meta (formerly Facebook) and Google. By providing useful products like search engines, these companies have lured consumers into giving away their personal data for free, and the companies use this information to detect buying patterns in order to sell advertising. The digital economy made high tech companies billions of dollars while many users became underemployed or jobless.
In recent years, a similar model has been emerging in the realm of genetics. Personalized genomic companies charge a relatively small fee to analyze a fraction of our genes and provide probabilities of having specific medical conditions. While individual data is not valuable, cumulative data is helpful for deep learning. So, these companies can sell the anonymous DNA data to pharmaceutical companies for millions of dollars.
As these companies improve their ability to collect even more data about our genetic vulnerabilities, the technologies of Web3 could protect consumers from giving it away for free. An emerging technology called blockchain is able to provide a Web-based ledger of financial transactions with checks and balances to ensure that its records cannot be faked or altered. It has yet to reach mass adoption by the public, but the computer scientist Jaron Lanier has proposed storing our genomes and electronic health records in blockchain, utilizing electronic smart contracts between individuals and pharma healthcare industry. Micropayments could then be made to individuals for their data, using cryptocurrency.
These individual payments could become more lucrative in the coming years especially as researchers learn how to fully interpret and apply a person’s genetic data. In this way, blockchain could lead to improvements in income inequality, which currently drives health problems and other challenges for many. A number of start-ups are using this business model which has secure data and eliminates middlemen who don’t create any value, while compensating and protecting the privacy of individuals who contribute their health data.
Autonomous Vehicles, Fog Computing and Pollution
A number of trends indicate that modernizing the transportation industry would address a myriad of problems with public health, productivity and the environment. Autonomous vehicles (AVs) could help usher in this new era of transportation, and these AVs would need to be supported by Web3 technologies.
Automobile accidents are the second leading cause of death worldwide, with roughly 1.3 million fatalities annually, according to the World Health Organization. Some estimates suggest that replacing human drivers with AVs could eliminate as many as a million global fatalities annually. Shared AVs would help to reduce traffic congestion that wastes time and fuel, and electric vehicles would help minimize greenhouse gases.
To reap the benefits from replacing gas vehicles with electric, societies will need an infrastructure that enables self-driving cars to communicate with each other. Most data processing in computers is performed using von Neumann architecture, where the data memory and the processor are in two different places. Today, that typically means cloud computing. With self-driving cars, when cameras and sensors generate data to detect objects on the roads, processors will need to rapidly analyze the data and make real-time decisions regarding acceleration, braking, and steering. However, cloud computing is susceptible to latency issues.
One solution to latency is moving processing and data storage closer to where it is needed to improve response times. Edge computing, for example, places the processor at the site where the data is generated. Most new human-driven vehicles contain anywhere from 30 to 100 electronic control units (ECUs) that process data and control electrical systems in vehicles. These embedded systems, typically in the dashboard, control different applications such as airbags, steering, brakes, etc. ECUs process data generated by cameras and sensors in AVs and make crucial decisions on how they operate.
Self-driving cars can benefit by communicating with each other for navigation in the same way that bacteria and animals use swarm intelligence for tasks involving groups. Researchers are currently investigating fog computing which utilizes servers along highways for faster and more reliable navigation and for communicating data analytics among driverless cars.
The Future Landscape of Web3 is Uncertain
The future of Web3 has many possibilities. However, there is no guarantee that blockchain, smart contracts, and fog computing will achieve public acceptance and market saturation or prevail over other technologies or the status quo of Web2. It is also uncertain if or when the breakthroughs in AI will occur that could eradicate complex diseases through Web3.
An example of this uncertainty is the metaverse, which combines blockchain with virtual reality. Currently, the metaverse is primarily used for gaming and recreational use until its infrastructure is further developed. Researchers are interested in the long-term mental health effects of virtual reality, both positive and negative. Using avatars, or virtual representations of humans, in the metaverse, users have greater control of their environment and chosen identities. But, it is unclear what negative mental health effects will occur. As far as regulations, the metaverse is still in the Wild West stage, and bullying or even murder will likely take place. Also, there will be a point where virtual worlds like the metaverse will become so immersive that we won't want to leave them, according to Meta’s Zuckerberg.
The metaverse would rely on virtual reality technology that was developed many years ago, and adoption has been slower than some experts predicted. But most emerging technologies, including other examples related to Web3, follow a similar, nonlinear pattern of development that Gartner has represented in graphical form using the S-curve. To develop a technology forecast for Web3, you can follow the progress along the curve from proof of concept to a particular goal. After a series of successes and failures, entrepreneurs will continue to improve their products until each emerging technology fails or achieves mainstream adoption by the public.
What mix of emerging technologies ultimately defines Web3 will likely be determined by the benefits they provide to society—including whether and how they improve health—how they stimulate the digital economy, and how they address the significant shortcomings of Web2.
This man spent over 70 years in an iron lung. What he was able to accomplish is amazing.
It’s a sight we don’t normally see these days: A man lying prone in a big, metal tube with his head sticking out of one end. But it wasn’t so long ago that this sight was unfortunately much more common.
In the first half of the 20th century, tens of thousands of people each year were infected by polio—a highly contagious virus that attacks nerves in the spinal cord and brainstem. Many people survived polio, but a small percentage of people who did were left permanently paralyzed from the virus, requiring support to help them breathe. This support, known as an “iron lung,” manually pulled oxygen in and out of a person’s lungs by changing the pressure inside the machine.
Paul Alexander was one of several thousand who were infected and paralyzed by polio in 1952. That year, a polio epidemic swept the United States, forcing businesses to close and polio wards in hospitals all over the country to fill up with sick children. When Paul caught polio in the summer of 1952, doctors urged his parents to let him rest and recover at home, since the hospital in his home suburb of Dallas, Texas was already overrun with polio patients.
Paul rested in bed for a few days with aching limbs and a fever. But his condition quickly got worse. Within a week, Paul could no longer speak or swallow, and his parents rushed him to the local hospital where the doctors performed an emergency procedure to help him breathe. Paul woke from the surgery three days later, and found himself unable to move and lying inside an iron lung in the polio ward, surrounded by rows of other paralyzed children.
Hospitals were commonly filled with polio patients who had been paralyzed by the virus before a vaccine became widely available in 1955. Associated Press
Paul struggled inside the polio ward for the next 18 months, bored and restless and needing to hold his breath when the nurses opened the iron lung to help him bathe. The doctors on the ward frequently told his parents that Paul was going to die.But against all odds, Paul lived. And with help from a physical therapist, Paul was able to thrive—sometimes for small periods outside the iron lung.
The way Paul did this was to practice glossopharyngeal breathing (or as Paul called it, “frog breathing”), where he would trap air in his mouth and force it down his throat and into his lungs by flattening his tongue. This breathing technique, taught to him by his physical therapist, would allow Paul to leave the iron lung for increasing periods of time.
With help from his iron lung (and for small periods of time without it), Paul managed to live a full, happy, and sometimes record-breaking life. At 21, Paul became the first person in Dallas, Texas to graduate high school without attending class in person, owing his success to memorization rather than taking notes. After high school, Paul received a scholarship to Southern Methodist University and pursued his dream of becoming a trial lawyer and successfully represented clients in court.
Paul Alexander, pictured here in his early 20s, mastered a type of breathing technique that allowed him to spend short amounts of time outside his iron lung. Paul Alexander
Paul practiced law in North Texas for more than 30 years, using a modified wheelchair that held his body upright. During his career, Paul even represented members of the biker gang Hells Angels—and became so close with them he was named an honorary member.Throughout his long life, Paul was also able to fly on a plane, visit the beach, adopt a dog, fall in love, and write a memoir using a plastic stick to tap out a draft on a keyboard. In recent years, Paul joined TikTok and became a viral sensation with more than 330,000 followers. In one of his first videos, Paul advocated for vaccination and warned against another polio epidemic.
Paul was reportedly hospitalized with COVID-19 at the end of February and died on March 11th, 2024. He currently holds the Guiness World Record for longest survival inside an iron lung—71 years.
Polio thankfully no longer circulates in the United States, or in most of the world, thanks to vaccines. But Paul continues to serve as a reminder of the importance of vaccination—and the power of the human spirit.
““I’ve got some big dreams. I’m not going to accept from anybody their limitations,” he said in a 2022 interview with CNN. “My life is incredible.”
When doctors couldn’t stop her daughter’s seizures, this mom earned a PhD and found a treatment herself.
Twenty-eight years ago, Tracy Dixon-Salazaar woke to the sound of her daughter, two-year-old Savannah, in the midst of a medical emergency.
“I entered [Savannah’s room] to see her tiny little body jerking about violently in her bed,” Tracy said in an interview. “I thought she was choking.” When she and her husband frantically called 911, the paramedic told them it was likely that Savannah had had a seizure—a term neither Tracy nor her husband had ever heard before.
Over the next several years, Savannah’s seizures continued and worsened. By age five Savannah was having seizures dozens of times each day, and her parents noticed significant developmental delays. Savannah was unable to use the restroom and functioned more like a toddler than a five-year-old.
Doctors were mystified: Tracy and her husband had no family history of seizures, and there was no event—such as an injury or infection—that could have caused them. Doctors were also confused as to why Savannah’s seizures were happening so frequently despite trying different seizure medications.
Doctors eventually diagnosed Savannah with Lennox-Gaustaut Syndrome, or LGS, an epilepsy disorder with no cure and a poor prognosis. People with LGS are often resistant to several kinds of anti-seizure medications, and often suffer from developmental delays and behavioral problems. People with LGS also have a higher chance of injury as well as a higher chance of sudden unexpected death (SUDEP) due to the frequent seizures. In about 70 percent of cases, LGS has an identifiable cause such as a brain injury or genetic syndrome. In about 30 percent of cases, however, the cause is unknown.
Watching her daughter struggle through repeated seizures was devastating to Tracy and the rest of the family.
“This disease, it comes into your life. It’s uninvited. It’s unannounced and it takes over every aspect of your daily life,” said Tracy in an interview with Today.com. “Plus it’s attacking the thing that is most precious to you—your kid.”
Desperate to find some answers, Tracy began combing the medical literature for information about epilepsy and LGS. She enrolled in college courses to better understand the papers she was reading.
“Ironically, I thought I needed to go to college to take English classes to understand these papers—but soon learned it wasn’t English classes I needed, It was science,” Tracy said. When she took her first college science course, Tracy says, she “fell in love with the subject.”
Tracy was now a caregiver to Savannah, who continued to have hundreds of seizures a month, as well as a full-time student, studying late into the night and while her kids were at school, using classwork as “an outlet for the pain.”
“I couldn’t help my daughter,” Tracy said. “Studying was something I could do.”
Twelve years later, Tracy had earned a PhD in neurobiology.
After her post-doctoral training, Tracy started working at a lab that explored the genetics of epilepsy. Savannah’s doctors hadn’t found a genetic cause for her seizures, so Tracy decided to sequence her genome again to check for other abnormalities—and what she found was life-changing.
Tracy discovered that Savannah had a calcium channel mutation, meaning that too much calcium was passing through Savannah’s neural pathways, leading to seizures. The information made sense to Tracy: Anti-seizure medications often leech calcium from a person’s bones. When doctors had prescribed Savannah calcium supplements in the past to counteract these effects, her seizures had gotten worse every time she took the medication. Tracy took her discovery to Savannah’s doctor, who agreed to prescribe her a calcium blocker.
The change in Savannah was almost immediate.
Within two weeks, Savannah’s seizures had decreased by 95 percent. Once on a daily seven-drug regimen, she was soon weaned to just four, and then three. Amazingly, Tracy started to notice changes in Savannah’s personality and development, too.
“She just exploded in her personality and her talking and her walking and her potty training and oh my gosh she is just so sassy,” Tracy said in an interview.
Since starting the calcium blocker eleven years ago, Savannah has continued to make enormous strides. Though still unable to read or write, Savannah enjoys puzzles and social media. She’s “obsessed” with boys, says Tracy. And while Tracy suspects she’ll never be able to live independently, she and her daughter can now share more “normal” moments—something she never anticipated at the start of Savannah’s journey with LGS. While preparing for an event, Savannah helped Tracy get ready.
“We picked out a dress and it was the first time in our lives that we did something normal as a mother and a daughter,” she said. “It was pretty cool.”