longevity

Repairing Cells and Longevity Myths with Dr. Charles Brenner

Podcast Face Offs
Repairing Cells and Longevity Myths with Dr. Charles Brenner

Charles Brenner, a leading biochemist at City of Hope National Medical Center in L.A., discovered a vitamin precursor called NR that seems to enable repair of cellular damage that happens as we get older.

Charles Brenner

Meet Charles Brenner, the Longevity Skeptic. Brenner, a leading biochemist at City of Hope National Medical Center in L.A., has been attending the largest longevity conferences with one main purpose: to point out that some of the other speakers are full of it.

Brenner is "throwing cold water" on several scientists in the field of aging, accusing them of hyping various fountains of youth, despite limited evidence for these therapies.

In this podcast episode, Brenner sat down with Leaps.org to discuss his groundbreaking work on metabolism and his efforts to counter what he considers to be bad science.



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In addition to bringing his candor to conferences, Brenner is applying it in academic journals, publishing a paper in September, "A Science-Based Review of the World's Best-Selling Book on Aging," in which he pans the author of this bestseller, David Sinclair, a Harvard biologist, for talking up the potential for humans to live far past 100. These aspirations may sound nice, but they're not backed by science, Brenner says. He's had high-profile debates online with Sinclair and Aubrey de Grey, a prominent biomedical gerontologist.

Meanwhile, in his own lab work, Brenner is credited with identifying a vitamin precursor called NR that seems to enable repair of cellular damage that happens as we get older - a major discovery that he's helped turn into a supplement, commercialized with a company called ChromaDex.

Whether it's possible to extend human lifespan is a pressing question as investments in longevity startups are projected to increase from $40 billion to $600 billion over the next three years. The field of biological aging seems split on the question of whether "anti-aging" therapies can significantly lengthen our natural lifespans, as Sinclair believes. Brenner, Morgan Levine of Altos Labs and Matt Kaeberlein of the University of Washington have argued that the only realistic goal is to extend one's window of healthy years, or healthspan, rather than trying to break the biological ceiling of our species.

Brenner is an intriguing figure in these debates. Although he’s been introduced in public appearances as a longevity skeptic, he calls himself an optimist.

Links:
Charles Brenner, City of Hope

Charles Brenner Lab

Charles Brenner on Twitter

Charles Brenner's debate with Aubrey de Grey

Brenner's paper, "A Science-Based Review of the World's Best-Selling Book on Aging"

Peter Attia's recent blog on NR supplements

Brad Stanfield's recent reaction to "David Sinclair vs Charles Brenner"

ChromaDex NR supplement

Matt Fuchs
Matt Fuchs is the host of the Making Sense of Science podcast and served previously as the editor-in-chief of Leaps.org. He writes as a contributor to the Washington Post, and his articles have also appeared in the New York Times, WIRED, Nautilus Magazine, Fortune Magazine and TIME Magazine. Follow him @fuchswriter.

Can Mental Health Apps Work for Depression?

Health Feature Story
Can Mental Health Apps Work for Depression?

Today’s more than 20,000 mental health apps have a wide range of functionalities and business models. Many of them can be useful for depression.

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Even before the pandemic created a need for more telehealth options, depression was a hot area of research for app developers. Given the high prevalence of depression and its connection to suicidality — especially among today’s teenagers and young adults who grew up with mobile devices, use them often, and experience these conditions with alarming frequency — apps for depression could be not only useful but lifesaving.

“For people who are not depressed, but have been depressed in the past, the apps can be helpful for maintaining positive thinking and behaviors,” said Andrea K. Wittenborn, PhD, director of the Couple and Family Therapy Doctoral Program and a professor in human development and family studies at Michigan State University. “For people who are mildly to severely depressed, apps can be a useful complement to working with a mental health professional.”

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L. Michael Posey
A pharmacist-editor-journalist since 1980, L. Michael Posey is a regular writer and editor for The Gerontological Society of America, Postgraduate Healthcare Education’s PowerPak.com website, and other clients. The author of several books and many news and journal articles, Posey is a founding editor of a landmark textbook in pharmacy, Pharmacotherapy: A Pathophysiologic Approach, a McGraw Hill title now in its 11th edition. He holds a master's degree in health and medical journalism and baccalaureate degrees in pharmacy and microbiology from the University of Georgia. Posey is the father of four sons and a daughter and resides in the Wine Country north of San Francisco. Follow him on Twitter @lmposey.
longevity

Podcast: Has the First 150-Year-Old Already Been Born

Podcast Health
Podcast: Has the First 150-Year-Old Already Been Born

In today's podcast episode, Steven Austad explains why we should want to live a long time as long as that involves longer healthspans.

Photo by Casey Andersen on Unsplash

Steven Austad is a pioneer in the field of aging, with over 200 scientific papers and book chapters on pretty much every aspect of biological aging that you could think of. He’s also a strong believer in the potential for anti-aging therapies, and he puts his money where his mouth is. In 2001, he bet a billion dollars that the first person to reach 150-years-old had already been born. I had a chance to talk with Steven for today’s podcast and asked if he still thinks the bet was a good idea, since the oldest person so far (that we know of), Jeanne Calment, died back in 1997. A few days after our conversation, the oldest person in the world, Kane Tanaka, died at 119.

Steven is the Protective Life Endowed Chair in Health Aging Research, a Distinguished Professor and Chair of the Department of Biology at the University of Alabama Birmingham. He's also Senior Scientific Director of the American Federation for Aging Research, which is managing a groundbreaking longevity research trial that started this year. Steven is also a great science communicator with five books, including one that comes out later this year, Methuselah’s Zoo, and he publishes prolifically in national media outlets.

See the rest of his bio linked below in the show notes.

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Matt Fuchs
Matt Fuchs is the host of the Making Sense of Science podcast and served previously as the editor-in-chief of Leaps.org. He writes as a contributor to the Washington Post, and his articles have also appeared in the New York Times, WIRED, Nautilus Magazine, Fortune Magazine and TIME Magazine. Follow him @fuchswriter.