Feature Story

Inside Scoop: How a DARPA Scientist Helped Usher in a Game-Changing Covid Treatment

Amy Jenkins is a program manager for the Defense Advanced Research Projects Agency's Biological Technologies Office, which runs a project called the Pandemic Prevention Platform.

Photo credit: Neil Jenkins

Amy Jenkins was in her office at DARPA, a research and development agency within the Department of Defense, when she first heard about a respiratory illness plaguing the Chinese city of Wuhan. Because she's a program manager for DARPA's Biological Technologies Office, her colleagues started stopping by. "It's really unusual, isn't it?" they would say.

At the time, China had a few dozen cases of what we now call COVID-19. "We should maybe keep an eye on that," she thought.

Early in 2020, still just keeping watch, she was visiting researchers working on DARPA's Pandemic Prevention Platform (P3), a project to develop treatments for "any known or previously unknown infectious threat," within 60 days of its appearance. "We looked at each other and said, 'Should we be doing something?'" she says.

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Sarah Scoles
Sarah Scoles is a freelance science journalist based in Denver. She is a contributing writer at Wired, a contributing editor at Popular Science, and the author of the book Making Contact: Jill Tarter and the Search for Extraterrestrial Intelligence.
New Hope for Organ Transplantation: Life Without Anti-Rejection Drugs

Kidney transplant patient Robert Waddell, center, with his wife and children after being off immunosuppresants; photo aken last summer in Perdido Key, FL. Left to right: Christian, Bailey, Rob, Karen (wife), Robby and Casey.

Photo courtesy Rob Waddell

Rob Waddell dreaded getting a kidney transplant. He suffers from a genetic condition called polycystic kidney disease that causes the uncontrolled growth of cysts that gradually choke off kidney function. The inherited defect has haunted his family for generations, killing his great grandmother, grandmother, and numerous cousins, aunts and uncles.

But he saw how difficult it was for his mother and sister, who also suffer from this condition, to live with the side effects of the drugs they needed to take to prevent organ rejection, which can cause diabetes, high blood pressure and cancer, and even kidney failure because of their toxicity. Many of his relatives followed the same course, says Waddell: "They were all on dialysis, then a transplant and ended up usually dying from cancers caused by the medications."

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Linda Marsa
Linda Marsa is a contributing editor at Discover, a former Los Angeles Times reporter and author of Fevered: Why a Hotter Planet Will Harm Our Health and How We Can Save Ourselves (Rodale, 2013), which the New York Times called “gripping to read.” Her work has been anthologized in The Best American Science Writing, and she has written for numerous publications, including Newsweek, U.S. News & World Report, Nautilus, Men’s Journal, Playboy, Pacific Standard and Aeon.
Out of Thin Air: A Fresh Solution to Farming’s Water Shortages

Dry, arid and remote farming regions are vulnerable to water shortages, but scientists are working on a promising new solution.

Photo by Amir Shahabi on Unsplash

California has been plagued by perilous droughts for decades. Freshwater shortages have sparked raging wildfires and killed fruit and vegetable crops. And California is not alone in its danger of running out of water for farming; parts of the Southwest, including Texas, are battling severe drought conditions, according to the North American Drought Monitor. These two states account for 316,900 of the 2 million total U.S. farms.

But even as farming becomes more vulnerable due to water shortages, the world's demand for food is projected to increase 70 percent by 2050, according to Guihua Yu, an associate professor of materials science at The University of Texas at Austin.

"Water is the most limiting natural resource for agricultural production because of the freshwater shortage and enormous water consumption needed for irrigation," Yu said.

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Katie Navarra
Katie Navarra is an award-winning writer who covers education, horses, farming, and business/leadership.